Discovery of A Novel Palladium Catalyst for the Preparation of Enynes with a Copper- and Ligand-Free Sonogashira Reaction
Xia Mi, Mengmeng Huang*, Yujian Feng, Yangjie Wu*
*Chemistry Department, Zhengzhou University, Zhengzhou
450052, P. R. of China, Email: wyjzzu.edu.cn, hmm
zzu.edu.cn
X. Mi, M. Huang, Y. Feng, Y. Wu, Synlett, 2012, 23, 1257-1261.
DOI: 10.1055/s-0031-1290938
Abstract
A palladium(II) complex based on N,N-dimethylethanolamine can be used as a catalyst in copper-free Sonogashira couplings of (E)- or (Z)-bromostyrenes with alkynes to produce conjugated enynes at room temperature in good yields with retention of the configuration.
see article for more examples
Key Words
N,N-dimethylethanolamine, copper-free, Sonogashira reaction, enynes, β-bromostyrenes, stereochemistry
ID: J60-Y2012-1620