One-Pot Synthesis of Trichloromethyl Carbinols from Primary Alcohols

Manoj K. Gupta, Zhexi Li and Timothy S. Snowden*

*Department of Chemistry, The University of Alabama, P.O. Box 870336, Tuscaloosa, Alabama 35487-0336, United States, Email: snowdenbama.ua.edu

M. K. Gupta, Z. Li, T. S. Snowden, J. Org. Chem., 2012, 77, 4854-4860.

DOI: 10.1021/jo300725v

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Abstract

Versatile trichloromethyl carbinols can be prepared in one pot from primary alcohols by treatment with Dess-Martin periodinane in CHCl₃ followed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD).

see article for more examples

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Key Words

Trichloromethyl Carbinols, Dess-Martin Periodinane

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ID: J42-Y2012-1630