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An Unexpected Silver Triflate Catalyzed Reaction of 2-Alkynylbenzaldehyde with 2-Isocyanoacetate

Danqing Zheng, Shaoyu Li and Jie Wu*

*Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China, Email:

D. Zheng, S. Li, J. Wu, Org. Lett., 2012, 14, 2655-2657.

DOI: 10.1021/ol300901x (free Supporting Information)


A silver triflate catalyzed reaction of 2-alkynylbenzaldehyde with 2-isocyanoacetate efficiently provides isoquinolines. The reaction proceeds smoothly in air under mild conditions with high efficiency.

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ID: J54-Y2012-1640