Merging Visible-Light Photocatalysis and Transition-Metal Catalysis in the Copper-Catalyzed Trifluoromethylation of Boronic Acids with CF₃I

Yingda Ye and Melanie S. Sanford*

*Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States, Email: mssanforumich.edu

Y. Ye, M. S. Sanford, J. Am. Chem. Soc., 2012, 134, 9034-9037.

DOI: 10.1021/ja301553c

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Abstract

A mild method for the trifluoromethylation of arylboronic acids has been developed via the merger of photoredox and Cu catalysis with CF₃I. This approach allows trifluoromethylation of electronically diverse aromatic and heteroaromatic substrates, and tolerates many common functional groups.

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Practical Method for the Cu-Mediated Trifluoromethylation of Arylboronic Acids with CF₃ Radicals Derived from NaSO₂CF₃ and tert-Butyl Hydroperoxide (TBHP)

Y. Ye, M. S. Sanford, J. Am. Chem. Soc., 2012, 134, 9034-9037.

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Key Words

Trifluoromethylation

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ID: J48-Y2012-1650