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Synthesis of Isocoumarin Derivatives via the Copper-Catalyzed Tandem Sequential Cyclization of 2-Halo-N-phenyl Benzamides and Acyclic 1,3-Diketones

Veerababurao Kavala, Cheng-Chuan Wang, Deepak Kumar Barange, Chun-Wei Kuo, Po-Min Lei and Ching-Fa Yao*

*Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei, Taiwan 116, R.O.C., Email:

V. Kavala, C.-C. Wang, D. K. Barange, C.-W. Kuo, P.-M. Lei, C.-F. Yao, J. Org. Chem., 2012, 77, 5022-5029.

DOI: 10.1021/jo300501j


A copper-catalyzed tandem C-C/C-O coupling strategy from readily available 2-iodo-N-phenyl benzamides and acyclic diketones as starting materials enables a facile and rapid synthesis of isocoumarin derivatives.

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ID: J42-Y2012-1660