Organocatalytic Dakin Oxidation by Nucleophilic Flavin Catalysts
Shuai Chen, Mohammad S. Hossain and Frank W. Foss, Jr*
*The University of Texas at Arlington, Department of
Chemistry and Biochemistry, Arlington, Texas 76019-0065, United States, Email:
ffoss
uta.edu
S. Chen, M. S. Hoassain, F. W. Foss, Jr, Org. Lett., 2012, 14, 2806-2809.
DOI: 10.1021/ol3010326
Abstract
An organocatalytic Dakin oxidation of electron-rich arylaldehydes to phenols can be performed under mild, basic conditions using flavin catalysts. Catechols are readily prepared and the oxidation of 2-hydroxyacetophenone was achieved.
see article for more examples
Aerobic Organocatalytic Oxidation of Aryl Aldehydes: Flavin Catalyst Turnover by Hantzsch's Ester
S. Chen, F. W. Foss, Jr, Org. Lett., 2012, 14, 5150-5153.
Key Words
Dakin Reaction, Organocatalysis
ID: J54-Y2012-1700
