De Novo Synthesis of 1,4-Dihydropyridines and Pyridines
Wafa Gati, Mohamed M. Rammah, Mohamed B. Rammah, François Couty and Gwilherm Evano*
*Laboratoire de Chimie Organique, Service de Chimie et
PhysicoChimie Organiques, Université Libre de Bruxelles, Avenue F. D. Roosevelt
50, CP160/06, 1050 Brussels, Belgium, Email: gevano
ulb.ac.be
W. Gati, M. M. Rammah, M. B. Rammah, F. Couty, G. Evano, J. Am. Chem. Soc., 2012, 134, 9078-9081.
DOI: 10.1021/ja303002a
Abstract
An efficient lithiation/isomerization/intramolecular carbolithiation sequence provides a divergent and straightforward entry to a wide range of polysubstituted dihydropyridines and pyridines starting from readily available N-allyl-ynamides.
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Key Words
ID: J48-Y2012-1780
