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De Novo Synthesis of 1,4-Dihydropyridines and Pyridines

Wafa Gati, Mohamed M. Rammah, Mohamed B. Rammah, François Couty and Gwilherm Evano*

*Laboratoire de Chimie Organique, Service de Chimie et PhysicoChimie Organiques, Université Libre de Bruxelles, Avenue F. D. Roosevelt 50, CP160/06, 1050 Brussels, Belgium, Email:

W. Gati, M. M. Rammah, M. B. Rammah, F. Couty, G. Evano, J. Am. Chem. Soc., 2012, 134, 9078-9081.

DOI: 10.1021/ja303002a


An efficient lithiation/isomerization/intramolecular carbolithiation sequence provides a divergent and straightforward entry to a wide range of polysubstituted dihydropyridines and pyridines starting from readily available N-allyl-ynamides.

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ID: J48-Y2012-1780