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Palladium-Catalyzed Conjugate Addition of Terminal Alkynes to Enones

Lara Villarino, Rebeca García-Fandiño, Fernando López* and José L. Mascareñas*

*Departamento de Química Orgánica, Unidad Asociada al CSIC, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain, Email: joseluis.mascarenasusc.es, fernando.lopeziqog.csic.es

L. Villarino, R. García, F. López, J. L. Mascareñas, Org. Lett., 2012, 14, 2996-2999.

DOI: 10.1021/ol300988n (free Supporting Information)


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Abstract

A practical Pd-catalyzed protocol for the hydroalkynylation of enones proceeds efficiently with various alkynes as well as with several cyclic and acyclic enones, providing synthetically relevant β-alkynyl ketones in good to excellent yields.

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Key Words

alkynylation, 1,4-addition


ID: J54-Y2012-1860