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Ruthenium-Catalyzed Highly Regioselective Cyclization of Ketoximes with Alkynes by C-H Bond Activation: A Practical Route to Synthesize Substituted Isoquinolines

Ravi Kiran Chinnagolla, Sandeep Pimparkar and Masilamani Jeganmohan *

*Department of Chemistry, Indian Institute of Science Education and Research, Pune 411021, India, Email: mjeganmohaniiserpune.ac.in

R. K. Chinnagolla, S. Pimparkar, M. Jeganmohan, Org. Lett., 2012, 14, 3032-3035.

DOI: 10.1021/ol301091z (free Supporting Information)


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Abstract

Aromatic and heteroaromatic ketoximes underwent a regioselective cyclization with alkynes in the presence of a catalytic amount of [{RuCl2(p-cymene)}2] and NaOAc to give isoquinoline derivatives in good to excellent yields.

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Key Words

Isoquinolines


ID: J54-Y2012-1920