Benzylation of Nitroalkanes Using Copper-Catalyzed Thermal Redox Catalysis: Toward the Facile C-Alkylation of Nitroalkanes
Peter G. Gildner, Amber A. S. Gietter, Di Cui and Donald A. Watson*
*Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States, Email: dawatsonudel.edu
P. G. Gildner, A. A. S. Gietter, D. Cui, D. A. Watson, J. Am. Chem. Soc., 2012, 134, 9942-9945.
DOI: 10.1021/ja304561c (free Supporting Information)
A simple Cu(I) catalyst, generated in situ, is highly effective for C-benzylation of nitroalkanes using abundant benzyl bromides and related heteroaromatic compounds. This process proceeds via a thermal redox mechanism and allows access to a variety of complex nitroalkanes under mild reaction conditions.
see article for more examples