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N,N-Diarylammonium Pyrosulfate as a Highly Effective Reverse Micelle-Type Catalyst for Hydrolysis of Esters

Yoshiki Koshikari, Akira Sakakura and Kazuaki Ishihara*

*Graduate School of Engineering and EcoTopia Science Institute, Nagoya University, Furo-cho, Chikusa, Nagoya, 464-8603, Japan, Email: ishiharacc.nagoya-u.ac.jp

Y. Koshikari, A. Sakakura, K. Ishihara, Org. Lett., 2012, 14, 3194-3197.

DOI: 10.1021/ol301290c (free Supporting Information)


Abstract

N,N-diarylammonium pyrosulfate efficiently catalyzes the hydrolysis of esters under organic solvent-free conditions. This reverse micelle-type method is successfully applied to the hydrolysis of various esters without the decomposition of base-sensitive moieties and without any loss of optical purity for α-heterosubstituted carboxylic acids.

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Key Words

hydrolysis (carboxylic acids, alcohols), acetic acid esters, methyl esters, green chemistry


ID: J54-Y2012-2020