Nickel-Catalyzed Coupling Reactions of Alkyl Electrophiles, Including Unactivated Tertiary Halides, To Generate Carbon-Boron Bonds
Alexander S. Dudnik and Gregory C. Fu*
*Department of Chemistry, Massachusetts Institute of
Technology, Cambridge, Massachusetts 02139, United States, Email: gcf
mit.edu
A. S. Dudnik, G. C. Fu, J. Am. Chem. Soc., 2012, 134, 10693-10697.
DOI: 10.1021/ja304068t
Abstract
A catalyst formed in situ from NiBr2 • diglyme and a pybox ligand accomplishes Miyaura-type borylations of unactivated tertiary, secondary, and primary alkyl halides with diboron reagents to furnish alkylboronates. The method exhibits good functional-group compatibility and is regiospecific.
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Key Words
Alkylboronates, Miyaura Borylation
ID: J48-Y2012-2030
