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Palladium-Catalyzed Tandem Amination Reaction for the Synthesis of 4-Quinolones

Tiankun Zhao and Bin Xu*

*Department of Chemistry, Shanghai University, Shanghai 200444, P. R. of China, Email:

T. Zhao, B. Xu, Org. Lett., 2010, 12, 212-215.

DOI: 10.1021/ol902626d (free Supporting Information)


An efficient palladium-catalyzed tandem amination approach affords functionalized 4-quinolones in very good yields from easily accessible o-haloaryl acetylenic ketones and primary amines.

see article for more examples

Synthesis of N-Alkyl-Substituted 4-Quinolones via Tandem Alkenyl and Aryl C-N Bond Formation

J. Shao, X. Huang, X. Hong, B. Liu, B. Xu, Synthesis, 2012, 44, 1798-1808.

Key Words


ID: J54-Y2010-3630