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Efficient Microwave-Assisted Pd-Catalyzed Hydroxylation of Aryl Chlorides in the Presence of Carbonate

Chao-Wu Yu, Grace S. Chen, Chen-Wei Huang and Ji-Wang Chern*

*School of Pharmacy, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan, Republic of China, Email:

C.-W. Yu, G. S. Chen, C.-W. Huang, J.-W. Chern, Org. Lett., 2012, 14, 3688-3691.

DOI: 10.1021/ol301523q


An efficient microwave-assisted, palladium-catalyzed hydroxylation converts aryl and heteroaryl chlorides to phenols in the presence of a weak base carbonate. The reaction tolerates ketone, aldehyde, ester, nitrile, or amide functionalities.

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Key Words

phenols, microwave synthesis

ID: J54-Y2012-2330