Organic Chemistry Portal

Abstracts

Search:

Palladium-Catalyzed, Asymmetric Mizoroki-Heck Reaction of Benzylic Electrophiles Using Phosphoramidites as Chiral Ligands

Zhigang Yang and Jianrong (Steve) Zhou*

*Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Email: jrzhountu.edu.sg

Z. Yang, J. Zhou, J. Am. Chem. Soc., 2012, 134, 11833-11835.

DOI: 10.1021/ja304099j



see article for more reactions

Abstract

A new phosphoramidite is an effective chiral ligand in a palladium-catalyzed asymmetric Mizoroki-Heck reaction using benzyl electrophiles. The reaction is compatible with polar functional groups and can be readily scaled up. Several cyclic olefins worked well as olefin components.

see article for more examples



Asymmetric Intermolecular Heck Reaction of Aryl Halides

C. Wu, J. Zhou, J. Am. Chem. Soc., 2014, 136, 650-652.


Key Words

2,5-Dihydrofurans, Cyclopentenes, Heck Reaction


ID: J48-Y2012-2350