Palladium-Catalyzed, Asymmetric Mizoroki-Heck Reaction of Benzylic Electrophiles Using Phosphoramidites as Chiral Ligands
Zhigang Yang and Jianrong (Steve) Zhou*
*Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Email: jrzhountu.edu.sg
Z. Yang, J. Zhou, J. Am. Chem. Soc., 2012, 134, 11833-11835.
DOI: 10.1021/ja304099j (free Supporting Information)
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A new phosphoramidite is an effective chiral ligand in a palladium-catalyzed asymmetric Mizoroki-Heck reaction using benzyl electrophiles. The reaction is compatible with polar functional groups and can be readily scaled up. Several cyclic olefins worked well as olefin components.
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C. Wu, J. Zhou, J. Am. Chem. Soc., 2014, 136, 650-652.