Palladium-Catalyzed, Asymmetric Mizoroki-Heck Reaction of Benzylic Electrophiles Using Phosphoramidites as Chiral Ligands
Zhigang Yang and Jianrong (Steve) Zhou*
*Division of Chemistry and Biological Chemistry, School of
Physical and Mathematical Sciences, Nanyang Technological University, Singapore
637371, Email: jrzhou
ntu.edu.sg
Z. Yang, J. Zhou, J. Am. Chem. Soc., 2012, 134, 11833-11835.
DOI: 10.1021/ja304099j
see article for more reactions
Abstract
A new phosphoramidite is an effective chiral ligand in a palladium-catalyzed asymmetric Mizoroki-Heck reaction using benzyl electrophiles. The reaction is compatible with polar functional groups and can be readily scaled up. Several cyclic olefins worked well as olefin components.
see article for more examples
Asymmetric Intermolecular Heck Reaction of Aryl Halides
C. Wu, J. Zhou, J. Am. Chem. Soc., 2014, 136, 650-652.
Key Words
2,5-Dihydrofurans, Cyclopentenes, Heck Reaction
ID: J48-Y2012-2350
