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Palladium-Catalyzed, Asymmetric Mizoroki-Heck Reaction of Benzylic Electrophiles Using Phosphoramidites as Chiral Ligands

Zhigang Yang and Jianrong (Steve) Zhou*

*Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Email: jrzhountu.edu.sg

Z. Yang, J. Zhou, J. Am. Chem. Soc., 2012, 134, 11833-11835.

DOI: 10.1021/ja304099j (free Supporting Information)



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Abstract

A new phosphoramidite is an effective chiral ligand in a palladium-catalyzed asymmetric Mizoroki-Heck reaction using benzyl electrophiles. The reaction is compatible with polar functional groups and can be readily scaled up. Several cyclic olefins worked well as olefin components.

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Asymmetric Intermolecular Heck Reaction of Aryl Halides

C. Wu, J. Zhou, J. Am. Chem. Soc., 2014, 136, 650-652.


Key Words

2,5-Dihydrofurans, Cyclopentenes, Heck Reaction


ID: J48-Y2012-2350