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Iron-Catalyzed Alkylations of Aryl Sulfamates and Carbamates

Amanda L. Silberstein, Stephen D. Ramgren and Neil K. Garg*

*Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569, United States, Email: neilgargchem.ucla.edu

A. L. Silberstein, S. D. Ramgren, N. K. Garg, Org. Lett., 2012, 14, 3796-3799.

DOI: 10.1021/ol301681z (free Supporting Information)



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Abstract

The alkylation of aryl sulfamates and carbamates using iron catalysis provides synthetically useful yields across a range of substrates. The directing group ability of sulfamates and carbamates, accompanied by their low reactivity toward conventional cross-couplings, renders these substrates useful for the synthesis of polyfunctionalized arenes.

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Key Words

arenes


ID: J54-Y2012-2360