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Copper(II)-Mediated Dehydrogenative Cross-Coupling of Heteroarenes

Zhifeng Mao, Zhe Wang, Zhaoqing Xu*, Fei Huang, Zhengkun Yu* and Rui Wang*

*Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China, and Lanzhou University, Lanzhou 730000, China, Email:,,

Z. F. Mao, Z. Wang, Z. Q. Xu, F. Huang, Z. K. Yu, R. Wang, Org. Lett., 2012, 14, 3854-3857.

DOI: 10.1021/ol301517y (free Supporting Information)


The use of Cu(OAc)2 enables a dehydrogenative cross-coupling between two heteroarenes via disproportionation of the copper mediator. This synthetic protocol provides a concise and "green" access to unsymmetrical biheteroarenes bearing structural motifs of substantial utility in organic synthesis.

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Key Words

Heterobiaryls, Copper(II)

ID: J54-Y2012-2410