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Transition-Metal-Free Synthesis of Oxindoles by Potassium tert-Butoxide-Promoted Intramolecular α-Arylation

Astrid Beyer, Julien Buendia and Carsten Bolm*

*Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, Germany, Email: carsten.bolmoc.rwth-aachen.de

A. Beyer, J. Buendia, C. Bolm, Org. Lett., 2012, 14, 3948-3951.

DOI: 10.1021/ol301704z (free Supporting Information)


Abstract

Potassium tert-butoxide-mediated intramolecular α-arylations of fluoro- and chloro-substituted anilides provide oxindoles in DMF at 80C. Diversely substituted products have been obtained in good yields.

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Key Words

Oxindoles


ID: J54-Y2012-2450