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Catalytic Radical Cation Salt Induced Csp3-H Functionalization of Glycine Derivatives: Synthesis of Substituted Quinolines

Xiaodong Jia*, Fangfang Peng, Chang Qing, Congde Huo and Xicun Wang*

*College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China, Email:,

X. Jia, F. Peng, C. Qing, C. Huo, X. Wang, Org. Lett., 2012, 14, 4030-4033.

DOI: 10.1021/ol301909g


A domino C-H functionalization of glycine derivatives for the production of a series of quinolines was achieved under catalytic radical cation salt induced conditions. A mechanism is proposed, that includes a peroxyl radical cation, which is generated by the coupling between O2 and TBPA+•.

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Key Words

Quinolines, Oxygen

ID: J54-Y2012-2510