An Improved Synthesis of Hydroxy Aryl Ketones by Fries Rearrangement with Methanesulfonic Acid/Methanesulfonic Anhydride
Ingyu Jeon*, Ian K. Mangion
*Department of Process Research, Merck and Co., Inc., PO Box
2000, Rahway, NJ 07065, Email: Ingyu.jeon
merck.com
I. Jeon, I. K. Mangion, Synlett, 2012, 23, 1927-1930.
DOI: 10.1055/s-0032-1316568
Abstract
Methanesulfonic acid treated with methanesulfonic anhydride effectively mediates the Fries rearrangement of aryl esters to give hydroxy aryl ketones with high yields.
see article for more examples
Key Words
Fries rearrangement, ketones, esters, methanesulfonic acid, methanesulfonic anhydride
ID: J60-Y2012-2530
