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An Improved Synthesis of Hydroxy Aryl Ketones by Fries Rearrangement with Methanesulfonic Acid/Methanesulfonic Anhydride

Ingyu Jeon*, Ian K. Mangion

*Department of Process Research, Merck and Co., Inc., PO Box 2000, Rahway, NJ 07065, Email:

I. Jeon, I. K. Mangion, Synlett, 2012, 23, 1927-1930.

DOI: 10.1055/s-0032-1316568


Methanesulfonic acid treated with methanesulfonic anhydride effectively mediates the Fries rearrangement of aryl esters to give hydroxy aryl ketones with high yields.

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Key Words

Fries rearrangement, ketones, esters, methanesulfonic acid, methanesulfonic anhydride

ID: J60-Y2012-2530