An Improved Synthesis of Hydroxy Aryl Ketones by Fries Rearrangement with Methanesulfonic Acid/Methanesulfonic Anhydride
Ingyu Jeon*, Ian K. Mangion
*Department of Process Research, Merck and Co., Inc., PO Box 2000, Rahway, NJ 07065, Email: Ingyu.jeonmerck.com
I. Jeon, I. K. Mangion, Synlett, 2012, 23, 1927-1930.
Methanesulfonic acid treated with methanesulfonic anhydride effectively mediates the Fries rearrangement of aryl esters to give hydroxy aryl ketones with high yields.
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Fries rearrangement, ketones, esters, methanesulfonic acid, methanesulfonic anhydride