Metal-Free, NHPI Catalyzed Oxidative Cleavage of C-C Double Bond Using Molecular Oxygen as Oxidant
Riyuan Lin, Feng Chen and Ning Jiao*
*State Key Laboratory of Natural and Biomimetic Drugs, Peking
University, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road
38, Beijing 100191, China, Email: jiaoning
bjmu.edu.cn
R. Lin, F. Chen, N. Jiao, Org. Lett., 2012, 14, 4158-4161.
DOI: 10.1021/ol3018215
Abstract
N-hydroxyphthalimide (NHPI) catalyzes a metal-free, aerobic oxidative cleavage of olefins. This methodology avoids the use of toxic metals or overstoichiometric amounts of traditional oxidants, showing good economical and environmental advantages. Based on the experimental observations, a plausible mechanism is proposed.
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Key Words
Cleavage of Alkenes, Oxygen, Green Chemistry, Organocatalysis
ID: J54-Y2012-2540
