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Geminal Alkene-Alkyne Cross Metathesis Using a Relay Strategy

Joseph R. Clark, Jonathan M. French, Edgars Jecs and Steven T. Diver*

*Department of Chemistry, University at Buffalo, The State University of New York, Amherst, New York 14260, United States, Email:

J. R. Clark, J. M. French, E. Jecs, S. T. Diver, Org. Lett., 2012, 14, 4178-4181.

DOI: 10.1021/ol301846q (free Supporting Information)


A relay strategy achieves an intermolecular ene-yne metathesis between 1,1-disubstituted alkenes and alkynes. This relay cross ene-yne metathesis gives rise to 1,1,3-trisubstituted-1,3-dienes previously inaccessible by direct ene-yne metathesis methods.

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proposed reaction pathway

Key Words

enyne metathesis

ID: J54-Y2012-2560