A Novel Strategy for the Construction of Azole Heterocycles via an Oxidative Desulfurization Approach Using Iodobenzene and Oxone
Kavitkumar N. Patel, Nikhil C. Jadhav, Prashant B. Jagadhane, Vikas N. Telvekar*
*Department of Pharmaceutical Sciences & Technology,
Institute of Chemical Technology, Matunga (E), Mumbai 400 019, India, Email:
vikastelvekar
rediffmail.com
K. N. Patel, N. C. Jadhav, P. B. Jagadhane, V. N. Telvekar, Synlett, 2012, 23, 1970-1972.
DOI: 10.1055/s-0031-1290439
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Abstract
An oxidative desulfurization approach enables the construction of oxadiazole and thiadiazole heterocycles in the presence of iodobenzene and Oxone. The use of iodobenzene and the inexpensive readily available oxidant Oxone makes the reaction system simple and versatile for desulfurization.
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Key Words
desulfurization, hypervalent iodine, iodobenzene, Oxone, thiosemicarbazide, oxadiazole
ID: J60-Y2012-2740
