A Mild, Palladium-Catalyzed Method for the Dehydrohalogenation of Alkyl Bromides: Synthetic and Mechanistic Studies
Alex C. Bissember, Anna Levina and Gregory C. Fu*
*Department of Chemistry, Massachusetts Institute of
Technology, Cambridge, Massachusetts 02139, United States, Email: gcfu
caltech.edu
A. C. Bissember, A. Levina, G. C. Fu, J. Am. Chem. Soc., 2012, 134, 14232-14237.
DOI: 10.1021/ja306323x
Abstract
β-Hydride elimination, an undesired elementary step in palladium-catalyzed cross-coupling reactions, allows dehydrohalogenations of alkyl bromides to form terminal olefins in excellent yield at room temperature in the presence of various functional groups.
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ID: J48-Y2012-2750
