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Room Temperature, Palladium-Mediated P-Arylation of Secondary Phosphine Oxides

Aaron J. Bloomfield and Seth B. Herzon*

*Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States, Email:

A. J. Bloomfield, S. B. Herzon, Org. Lett., 2012, 14, 4370-4373.

DOI: 10.1021/ol301831k (free Supporting Information)


A broad range of aryl iodides are efficiently coupled with secondary phosphine oxides using low loadings of a catalyst formed in situ from tris(dibenzylideneacetone)dipalladium and Xantphos.

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Key Words

phosphine oxides, phosphonates

ID: J54-Y2012-2820