One-Step Cyclization: Synthesis of N-Heteroalkyl-N′-tosylpiperazines

Jianying Huang*, Weiyuan Xu, Hujun Xie and Shijun Li*

*Zhejiang Gongshang University, Hangzhou 310035, P. R. China, Hangzhou Normal University, Hangzhou 310036, P. R. China, Email: huangjymail.zjgsu.edu.cn, l_shijunhznu.edu.cn

J. Huang, W. Xu, H. Xie, S. Li, J. Org. Chem., 2012, 77, 7506-7511.

DOI: 10.1021/jo3012896

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Abstract

A practical method allows the synthesis of alkyl-, alcohol-, amine-, and ester-extended tosylpiperazines under mild conditions with good yields. This protocol exhibits potential applicability in the synthesis of pharmaceuticals and natural products because of the operational simplicity and the conveniently available reactants.

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Key Words

Piperazines

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ID: J42-Y2012-2830