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Facile, Selective, and Regiocontrolled Synthesis of Oxazolines and Oxazoles Mediated by ZnI2 and FeCl3

Gopal Chandru Senadi, Wan-Ping Hu, Jia-Shing Hsiao, Jaya Kishore Vandavasi, Chung-Yu Chen and Jeh-Jeng Wang*

*Departments of Medicinal and Applied Chemistry, Biotechnology, and Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Email: jjwangkmu.edu.tw

G. C. Senadi, W.-P. Hu, J.-S. Hsiao, J. K. Vandavasi, C.-Y. Chen, J.-J. Wang, Org. Lett., 2012, 14, 4478-4481.

DOI: 10.1021/ol301980g (free Supporting Information)


Abstract

ZnI2 and FeCl3 mediate a direct approach to the selective and regiocontrolled synthesis of 2-oxazolines and 2-oxazoles in very good yields under mild reaction conditions by cyclization of acetylenic amides. Various functionalities were well tolerated.

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Key Words

2-Oxazolines, Oxazoles


ID: J54-Y2012-2870