pH-Independent Transfer Hydrogenation in Water: Catalytic, Enantioselective Reduction of β-Keto Esters
Martin A. Ariger and Erick M. Carreira*
*Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg,
Switzerland, Email: carreira
org.chem.ethz.ch
M. A. Ariger, E. M. Carreira, Org. Lett., 2012, 14, 4522-4524.
DOI: 10.1021/ol301903c
Abstract
A pH-independent asymmetric transfer hydrogenation of β-keto esters in water with formic acid/sodium formate can be conducted open to air and gives access to β-hydroxy esters in excellent yields and selectivities.
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Key Words
Formic Acid, Reduction of Carbonyl Compounds, β-Hydroxy Esters
ID: J54-Y2012-2890
