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A Greener Protocol for Accessing 2,3-Dihydro/spiroquinazolin-4(1H)-ones: Natural Acid-SDS Catalyzed Three-Component Reaction

Rashmi Sharma, Anand Kumar Pandey, Prem M. S. Chauhan*

*Division of Medicinal and Process Chemistry, CSIR Central Drug Research Institute, Lucknow 226001, India, Email:

R. Sharma, A. K. Pandey, P. M. S. Chauhan, Synlett, 2012, 23, 2209-2214.

DOI: 10.1055/s-0032-1317014

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Utilizing a recyclable tartaric acid-SDS catalyst system help to achieve a green synthesis of 2,3-dihydro/spiroquinazolin-4(1H)-ones via three-component cyclocondensation reaction of isatoic anhydride, amines and aldehydes/ketones. Mechanochemical activation at room temperature lead to significant improvement on previously described methods for the synthesis of such compounds even in large-scale reactions.

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Key Words

2,3-dihydroquinazolin-4(1H)-ones, mechanochemical activation, multicomponent reactions, sodium dodecyl sulfate (SDS), tartaric acid, green chemistry

ID: J60-Y2012-2950