Efficient Synthesis of γ-Lactones via Gold-Catalyzed Tandem Cycloisomerization/Oxidation
Chao Shu, Meng-Qi Liu, Yu-Zhe Sun and Long-Wu Ye*
*Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, P. R. China, Email: longwuyexmu.edu.cn
C. Shu, M.-Q. Liu, Y-Z. Sun, L.-W. Ye, Org. Lett., 2012, 14, 4958-4961.
DOI: 10.1021/ol302323a (free Supporting Information)
Various γ-lactones can be accessed readily by utilizing a Au-catalyzed tandem cycloisomerization/oxidation of homopropargyl alcohols. Notably, the mechanism of this strategy is distinctively different from the related Ru-catalyzed reactions where a ruthenium vinylidene intermediate occurs.
see article for more examples