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Palladium(II)-Catalyzed Enantioselective Arylation of α-Imino Esters

Jiayan Chen, Xiaoxia Lu, Wenyong Lou, Yong Ye, Huanfeng Jiang and Wei Zeng*

*School of Chemistry and Chemical Engineering, South China University of Technology, No. 381, Wushan Road, Tianhe District, Guangzhou 510640, People's Republic of China, Email:

J. Chen, X. Lu, W. Lou, Y. Ye, H. Jiang, W. Zeng, J. Org. Chem., 2012, 77, 8541-8548.

DOI: 10.1021/jo301423e (free Supporting Information)

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A protocol for Pd(II)-catalyzed asymmetric arylation of N-aryl imino esters affords a practical and direct access to chiral arylglycine derivatives in good yields and with high enantioselectivities.

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Key Words

amino acids, α-arylation

ID: J42-Y2012-3160