Aerobic Organocatalytic Oxidation of Aryl Aldehydes: Flavin Catalyst Turnover by Hantzsch's Ester
Shuai Chen and Frank W. Foss, Jr*
*The University of Texas at Arlington, Department of Chemistry and Biochemistry, Arlington, Texas 76019-0065, United States, Email: ffossuta.edu
S. Chen, F. W. Foss, Jr, Org. Lett., 2012, 14, 5150-5153.
DOI: 10.1021/ol302479b (free Supporting Information)
The use of flavin organocatalysts and a Hantzsch ester enabled a transition-metal-free Dakin oxidation fueled by molecular oxygen as the terminal oxidant. Catechols and electron-rich phenols are achieved with low catalyst loadings, in the presence of Hantzsch ester, and O2 or air as the stoichiometric oxidant source.
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S. Chen, M. S. Hoassain, F. W. Foss, Jr, Org. Lett., 2012, 14, 2806-2809.