Organic Chemistry Portal



Aerobic Organocatalytic Oxidation of Aryl Aldehydes: Flavin Catalyst Turnover by Hantzsch's Ester

Shuai Chen and Frank W. Foss, Jr*

*The University of Texas at Arlington, Department of Chemistry and Biochemistry, Arlington, Texas 76019-0065, United States, Email:

S. Chen, F. W. Foss, Jr, Org. Lett., 2012, 14, 5150-5153.

DOI: 10.1021/ol302479b


The use of flavin organocatalysts and a Hantzsch ester enabled a transition-metal-free Dakin oxidation fueled by molecular oxygen as the terminal oxidant. Catechols and electron-rich phenols are achieved with low catalyst loadings, in the presence of Hantzsch ester, and O2 or air as the stoichiometric oxidant source.

see article for more examples

Organocatalytic Dakin Oxidation by Nucleophilic Flavin Catalysts

S. Chen, M. S. Hoassain, F. W. Foss, Jr, Org. Lett., 2012, 14, 2806-2809.

Key Words

Dakin Reaction, Organocatalysis, Oxygen

ID: J54-Y2012-3270