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Copper-Catalyzed Amination of Silyl Ketene Acetals with N-Chloroamines

Tomoya Miura*, Masao Morimoto and Masahiro Murakami*

*Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Katsura, Kyoto 615-8510, Japan, Email:,

T. Miura, M. Morimoto, M. Murakami, Org. Lett., 2012, 14, 5214-5217.

DOI: 10.1021/ol302331k (free Supporting Information)


A copper(I)/2,2′-bipyridyl complex catalyzes an amination reaction of silyl ketene acetals with N-chloroamines to give α-amino esters in good yield.

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Key Words

α-amino esters

ID: J54-Y2012-3290