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N-Heterocyclic Carbene-Palladium(II)-1-Methylimidazole Complex Catalyzed Amination between Aryl Chlorides and Amides

Wen-Xin Chen and Li-Xiong Shao*

*College of Chemistry and Materials Engineering, Wenzhou University, Chashan University Town, Wenzhou, Zhejiang Province 325035, People's Republic of China, Email:

W.-X. Chen, L-X. Shao, J. Org. Chem., 2012, 77, 9236-9239.

DOI: 10.1021/jo301811n


Amides are excellent N-sources in the NHC-Pd(II)-Im complex catalyzed amination of aryl chlorides. In the presence of KOtBu, various aryl chlorides and amides react smoothly to give the corresponding aminated products in good yields at room temperature within 6 h.

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ID: J42-Y2012-3320