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Pd-Catalyzed Cascade Reaction for the Synthesis of 2-Substituted Indoles

Jagannath Jadhav, Vipul Gaikwad, Rajanikant Kurane, Rajashri Salunkhe, Gajanan Rashinkar*

*Department of Chemistry, Shivaji University, Kolhapur 416004, M.S., India, Email: gsr_chemunishivaji.ac.in

J. Jadhav, V. Gaikwad, R. Kurane, R. Salunkhe, G. Rahsinkar, Synlett, 2012, 23, 2511-2515.

DOI: 10.1055/s-0032-1317320


Abstract

An efficient cascade methodology toward the synthesis of 2-substituted indoles proceeds via a palladium-catalyzed cross-coupling reaction of o-nitrobenzyl cyanides with boronic acids in the presence of Fe as co-catalyst.


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Key Words

cascade synthesis, 2-substituted indoles, palladium-catalyzed cross-coupling reaction


ID: J60-Y2012-3360