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Conjugate Hydrocyanation of Aromatic Enones Using Potassium Hexacyanoferrate(II) as an Eco-Friendly Cyanide Source

Zheng Li*, Chenhui Liu, Yupeng Zhang, Rongzhi Li, Ben Ma, Jingya Yang

*College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, P. R. of China, Email:

Z. Li, C. Liu, Y. Zhang, R. Li, B. Ma, J. Yang, Synlett, 2012, 23, 2567-2571.

DOI: 10.1055/s-0032-1317179


A selective conjugate hydrocyanation of aromatic enones by a one-pot, two-step procedure takes place in the presence of potassium hexacyanoferrate(II) as an original eco-friendly cyanide source, potassium hydroxide as a base, and benzoyl chloride as a promoter. This protocol has the advantages of a nontoxic cyanide source, high yield, and simple workup procedure.

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Key Words

cyanation, conjugate hydrocyanation, 1,4-addition, aromatic enone, green chemistry, nucleophilic addition, potassium hexacyanoferrate(II)

ID: J60-Y2012-3430