Efficient, One-Pot, BF3ˇOEt2-Mediated Synthesis of Substituted N-Aryl Lactams
Devdutt Chaturvedi*, Amit K. Chaturvedi, Nisha Mishra, Virendra Mishra
*Laboratory of Medicinal Chemistry, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus, Lucknow 226010, U. P., India, Email: devduttchaturvedigmail.com
D. Caturvedi, A. K. Chaturvedi, N. Mishra, V. Mishra, Synlett, 2012, 23, 2627-2630.
A quick, efficient, one-pot, BF3ˇOEt2-mediated reaction of various substituted arenes with azido alkanoic acid chlorides affords substituted N-aryl lactams in good to excellent yields at room temperature.
see article for more examples
substituted arenes, ω-azido-alkanoic acid chloride, Lewis acid, N-aryl lactams, lactams, Friedel-Crafts acylation, Schmidt reaction