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Unexpected C-C Bond Cleavage: A Route to 3,6-Diarylpyridazines and 6-Arylpyridazin-3-ones from 1,3-Dicarbonyl Compounds and Methyl Ketones

Qinghe Gao, Yanping Zhu, Mi Lian, Meicai Liu, Jingjing Yuan, Guodong Yin* and Anxin Wu*

*Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China, Email: gdyinhbnu.edu.cn, chwuaxmail.ccnu.edu.cn

Q. Gao, Y. Zhu, M. Lian, M. Liu, J. Yuan, G. Yin, A. Wu, J. Org. Chem., 2012, 77, 9865-9870.

DOI: 10.1021/jo301751e (free Supporting Information)


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Abstract

An unexpected C-C bond cleavage in the absence of metal enables an efficient approach toward 3,6-diarylpyridazines and 6-arylpyridazin-3-ones from simple and commercially available 1,3-dicarbonyl compounds and methyl ketones.

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Key Words

pyridazines


ID: J42-Y2012-3520