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Highly Chemoselective Metal-Free Reduction of Phosphine Oxides to Phosphines

Yuehui Li, Liang-Qiu Lu, Shoubhik Das, Sabine Pisiewicz, Kathrin Junge and Matthias Beller*

*Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert Einstein Str. 29a, 18059 Rostock, Germany, Email: matthias.bellercatalysis.de

Y. Li, L.-Q. Lu, S. Das, S. Pisiewicz, K. Junge, M. Beller, J. Am. Chem. Soc., 2012, 134, 18325-18329.

DOI: 10.1021/ja3069165 (free Supporting Information)


Abstract

Unprecedented chemoselective reductions of phosphine oxides to phosphines with inexpensive silanes proceed smoothly in the presence of catalytic amounts of specific phosphoric acid esters. The reaction tolerates ketones, aldehydes, olefins, nitriles, and esters under the optimized conditions.


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General and Selective Copper-Catalyzed Reduction of Tertiary and Secondary Phosphine Oxides: Convenient Synthesis of Phosphines

Y. Li, S. Das, S. Zhou, K. Junge, M. Beller, J. Am. Chem. Soc., 2012, 134, 9727-9732.


Key Words

Reduction of Phosphine Oxides, Diethoxymethylsilane


ID: J48-Y2012-3550