Synthesis of Coumarins via Pd-Catalyzed Oxidative Cyclocarbonylation of 2-Vinylphenols
Jamie Ferguson, Fanlong Zeng and Howard Alper*
*Centre for Catalysis Research and Innovation, Department of
Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada, K1N
6N5, Email: howard.alper
uottawa.ca
J. Ferguson, F. Zeng, H. Alper, Org. Lett., 2012, 14, 5602-5605.
DOI: 10.1021/ol302725x
see article for more reactions
Abstract
Palladium-catalyzed oxidative cyclocarbonylation of 2-vinylphenols enables a direct synthesis of various coumarins in good yields in the presence of low pressures of CO, and air or 1,4- benzoquinone as the oxidant. The reaction conditions are attractive in terms of environmental considerations and operational simplicity.
see article for more examples
Key Words
ID: J54-Y2012-3610
