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Pd-Catalyzed Synthesis of Aryl Amines via Oxidative Aromatization of Cyclic Ketones and Amines with Molecular Oxygen

Simon A. Girard, Xiong Hu, Thomas Knauber, Feng Zhou, Marc-Olivier Simon, Guo-Jun Deng* and Chao-Jun Li*

*Department of Chemistry, McGill University, Montreal, QC, H3A 2K6, Canada and College of Chemistry, Xiangtan University, Xiangtan 411105, China, Email:,

S. A. Girard, X. Hu, T. Knauber, F. Zhou, M.-O. Simon, G.-J. Deng, C.-J. Li, Org. Lett., 2012, 14, 5606-5609.

DOI: 10.1021/ol3027279

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Pd-catalyzed intermolecular aerobic dehydrogenative aromatizations enable the arylation of amines with cyclohexanones and 2-cyclohexen-1-ones. Under optimized reaction conditions, primary and secondary amines are selectively arylated in good yields under an atmosphere of molecular oxygen.

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Key Words

Aryl Amines, Oxygen

ID: J54-Y2012-3630