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Synthesis of Oxazoles from Enamides via Phenyliodine Diacetate-Mediated Intramolecular Oxidative Cyclization

Yunhui Zheng, Xuming Li, Chengfeng Ren, Daisy Zhang-Negrerie, Yunfei Du* and Kang Zhao*

*Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China, Email:,

Y. Zheng, X. Li, C. Ren, D. Zhang-Negrerie, Y. Du, K. Zhao, J. Org. Chem., 2012, 77, 10353-10361.

DOI: 10.1021/jo302073e


A broad range of functionalized oxazoles were synthesized in good yields from enamides via phenyliodine diacetate (PIDA)-mediated intramolecular cyclization. The oxidative carbon-oxygen bond formation process is heavy-metal-free.

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Key Words

Oxazoles, PIDA

ID: J42-Y2012-3700