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"One-Pot" Synthesis of 4-Substituted 1,5-Diaryl-1H-pyrazole-3-carboxylic Acids via a MeONa/LiCl-Mediated Sterically Hindered Claisen Condensation-Knorr Reaction-Hydrolysis Sequence

Jian-An Jiang, Cai-Yan Du, Chun-Hui Gu, Ya-Fei Ji*

*School of Pharmacy, East China University of Science & Technology, Campus P. O. Box 363, 130 Meilong Road, Shanghai 200237, P. R. of China, Email:

J.-A. Jiang, C.-Y. Du, C.-H. Gu, Y.-F. Ji, Synlett, 2012, 23, 2965-2968.

DOI: 10.1055/s-0032-1317668

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A concise, efficient and green "one-pot" synthesis of 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylic acids was composed of MeONa/LiCl-mediated sterically hindered Claisen condensation, Knorr reaction and hydrolysis.

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Key Words

MeONa/LiCl, Claisen condensation, Knorr reaction, 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylic acids, pyrazoles

ID: J60-Y2012-3850