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A Mild and Efficient Synthesis of 2-Oxazolines via Transamidation-Cyclodehydrosulfurisation of Thioamides with 2-Aminoethanol

D. Raghavender Goud, Uma Pathak*

*Synthetic Chemistry Division, Defence R & D Establishment, Jhansi Road, Gwalior 474002 (M.P.), India, Email: sc_drderediffmail.com

D. R. Goud, U. Pathak, Synthesis, 2012, 44, 3678-3682.

DOI: 10.1055/s-0032-1317341 (free Supporting Information)


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Abstract

Transamidation of thioamides with 2-aminoethanol, followed by cyclodehydrosulfurisation of the resultant N-(β-hydroxyethyl)thioamides, enables a mild and efficient synthesis of 2-oxazolines.

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Key Words

2-oxazolines, thioamides, 2-aminoethanol, transamidation, cyclodehydrosulfurisation


ID: J66-Y2012-3880