A Mild and Efficient Synthesis of 2-Oxazolines via Transamidation-Cyclodehydrosulfurisation of Thioamides with 2-Aminoethanol
D. Raghavender Goud, Uma Pathak*
*Synthetic Chemistry Division, Defence R & D Establishment,
Jhansi Road, Gwalior 474002 (M.P.), India, Email: sc_drde
rediffmail.com
D. R. Goud, U. Pathak, Synthesis, 2012, 44, 3678-3682.
DOI: 10.1055/s-0032-1317341
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Abstract
Transamidation of thioamides with 2-aminoethanol, followed by cyclodehydrosulfurisation of the resultant N-(β-hydroxyethyl)thioamides, enables a mild and efficient synthesis of 2-oxazolines.
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Key Words
2-oxazolines, thioamides, 2-aminoethanol, transamidation, cyclodehydrosulfurisation
ID: J66-Y2012-3880
