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Trifluoromethylation of Alkenes by Visible Light Photoredox Catalysis

Naeem Iqbal, Sungkyu Choi, Eunjin Kim and Eun Jin Cho*

*Department of Chemistry and Applied Chemistry, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, ansan, Kyeonggi-do 426-791, Republic of Korea, Email: echohanyang.ac.kr

N. Iqbal, S. Choi, E. Kim, E. J. Cho, J. Org. Chem., 2012, 77, 11383-11387.

DOI: 10.1021/jo3022346 (free Supporting Information)


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Abstract

A method for trifluoromethylation of alkenes uses visible light photoredox catalysis with CF3I, Ru(Phen)3Cl2, and DBU. This process works especially well for terminal alkenes to give alkenyl-CF3 products with only E-stereochemistry and tolerates various functional groups.

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Key Words

trifluoromethyl alkenes


ID: J42-Y2012-3900