A New Catalyst for the Asymmetric Henry Reaction: Synthesis of β-Nitroethanols in High Enantiomeric Excess
James D. White * and Subrata Shaw
*Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, United States, Email: James.whiteoregonstate.edu
J. D. White, S. Shaw, Org. Lett., 2012, 14, 6270-6273.
A complex of copper(I) and a chiral tetrahydrosalen ligand was an efficient catalyst for the asymmetric Henry reaction, producing nitroaldol products in high yield and good stereoselectivity. Henry reactions catalyzed by this tetrahydrosalen-Cu(I) complex led to syntheses of β-adrenergic blocking agents (S)-toliprolol, (S)-moprolol, and (S)-propanolol.
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