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An Efficient Synthesis of 2-Aminothiophenes via the Gewald Reaction Catalyzed by an N-Methylpiperazine-Functionalized Polyacrylonitrile Fiber

Lichao Ma, Liwei Yuan, Changzhu Xu, Guowei Li, Minli Tao, Wenqin Zhang*

*Department of Chemistry, School of Sciences, Tianjin University, No.92 Weijin Road, Tianjin 300072, P. R. of China, Email:

L. Ma, L. Yuan, C. Xu, G. Li, M. Tao, W. Zhang, Synthesis, 2013, 45, 45-52.

DOI: 10.1055/s-0032-1316821

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A N-methylpiperazine-functionalized polyacrylonitrile fiber catalyzes the Gewald reaction between 2,5-dihydroxy-1,4-dithiane and activated nitriles to afford 3-substituted 2-aminothiophenes in very good yields. Low catalyst loading, simple procedure and excellent recyclability are attractive features of this fiber catalyst.

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Key Words

Gewald reaction, 2-aminothiophenes, N-methylpiperazine, polyacrylonitrile fiber, fiber catalyst

ID: J66-Y2013-0050