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Cu(OTf)2-Catalyzed Synthesis of 2,3-Disubstituted Indoles and 2,4,5-Trisubstituted Pyrroles from α-Diazoketones

B. V. Subba Reddy*, M. Ramana Reddy, Y. Gopal Rao, J. S. Yadav and B. Sridhar

*Natural Product Chemistry, Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad, 500 007, India, Email:

B. V. S. Reddy, M. R. Reddy, Y. G. Rao, J. S. Yadav, B. Srighar, Org. Lett., 2013, 15, 464-467.

DOI: 10.1021/ol303206w


The use 10 mol % of Cu(OTf)2 enables the coupling of α-diazoketones with β-enaminoketones and esters to yield 2,4,5-trisubstituted pyrrole derivatives. A wide range of 2,3-disubstituted indole derivatives were also prepared from α-diazoketones and 2-aminoaryl or alkyl ketones.

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Key Words

Indoles, Pyrroles

ID: J54-Y2013-0260