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Direct Access to Acylated Azobenzenes via Pd-Catalyzed C-H Functionalization and Further Transformation into an Indazole Backbone

Hongji Li, Pinhua Li and Lei Wang*

*Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P.R. China, Email:

H. Li, P. Li, L. Wang, Org. Lett., 2013, 15, 620-623.

DOI: 10.1021/ol303434n

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Azobenzenes were readily acylated at the 2-position with aldehydes in good yields through a Pd-catalyzed C-H functionalization in the presence of TBHP. The obtained acylated azobenzenes could be efficiently converted into the corresponding indazole derivatives in nearly quantitative yields.

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Key Words

2H-Indazoles, Zinc

ID: J54-Y2013-0340