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Hydrogen-Free Alkene Reduction in Continuous Flow

Andrew S. Kleinke and Timothy F. Jamison*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States, Email:

A. S. Kleinke, T. F. Jamison, Org. Lett., 2013, 15, 710-713.

DOI: 10.1021/ol400051n (free Supporting Information)

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In a simple continuous hydrogenation of alkenes and alkynes, that requires neither H2 nor metal catalysis, diimide is generated in situ by a novel reagent combination. A simple flow reactor employed minimizes residence time and enables safe operation at elevated temperature.

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Key Words

reduction of alkenes, flow chemistry

ID: J54-Y2013-0410